Berner-Garde Success Stories - Berner-Garde Foundation

Most of us are familiar with how many owners or breeders use the Berner-Garde Database to research dogs and pedigrees. However, many people may not be aware of how Berner-Garde also works with the scientific community to assist them in their research efforts. These efforts could be identifying genetic causes of diseases or searching for potential treatments to help keep our dogs healthy. Listed here are some of the efforts we have been involved in. Links to published research papers are provided when available.

Researchers, for information about applying for repository samples or database extracts, please see our Research page by clicking here.

Transcriptome Analysis of Canine Histiocytic Sarcoma Tumors and Cell Lines Reveals Multiple Targets for Therapy

Published March, 2025. https://www.mdpi.com/2072-6694/17/6/954

Canine Histiocytic and Hemophagocytic Histiocytic Sarcomas Display KRAS and Extensive PTPN11/SHP2 Mutations and Respond In Vitro to MEK Inhibition by Cobimetinib

Published August, 2024. https://www.mdpi.com/2073-4425/15/8/1050

Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas

Published July, 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678586/

Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and its Use in Evaluating the Efficacy of Treatment with Dasatinib

Published February, 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382049/

Targeting MEK in a translational model of Histiocytic Sarcoma

Published August, 2018. https://mct.aacrjournals.org/content/molcanther/early/2018/08/22/1535-7163.MCT-17-1273.full.pdf

Gain-of-Function mutation in PTPN11 in Histiocytic Sarcomas of Bernese Mountain Dogs

Published June, 2018. https://www.ncbi.nlm.nih.gov/pubmed/28929581

A novel histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies

Published March, 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831740/

Genetic progress in the fight against histiocytic sarcoma. Genetic risk test: HS test

Presented in 2017. http://bernese.co.uk/health/wp-content/uploads/sites/3/IWG-2017-B-Hedan.pdf

Novel Compounds to Treat Histiocytic Sarcoma and Other Malignancies

Published August, 2017. https://msut.technologypublisher.com/technology/25997

Risk Factors Associated with Development of Histiocytic Sarcoma in Bernese Mountain Dogs

Published May, 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084741/

Inheritance of histiocytosis in Bernese mountain dogs